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Approximately 600,000 patients with Clostridium difficile-associated
colitis are reported each year in the U. S., resulting in prolonged hospitalizations and
approximately 5,000 deaths. Ulcerative colitis is a disease that causes inflammation
and sores, called ulcers, in the lining of the large intestine. The inflammation usually
occurs in the rectum and lower part of the colon, but it may affect the entire colon.
Ulcerative colitis rarely affects the small intestine except for the end section, called
the terminal ileum. Ulcerative colitis may also be called colitis or proctitis.
Phage Therapy
Phage Therapy Center
Phage Therapy Center treats antibiotic-resistant infections. [More information...]
Additional Information About Phage Therapy for this Condition
Evergreen State College
Phage Therapy as Antibiotics
March
2000 Addendum
Medical Immunology
New insights
into the possible role of bacteriophages in host defense and disease
Applied and Environmental Microbiology
Biocontrol of Escherichia
coli O157 with O157-Specific Bacteriophages
American Society for Microbiology
Morphological,
Host Range, and Genetic Characterization of Two Coliphages
Eliava Institute
List of Bacteriophages
Medical Information
Patient Health International
Crohn's Disease
BBC News, 16 September, 2004,
'Clear'
bacteria link to Crohn's
Mycobacterium avium subspecies paratuberculosis (Map) was found for the first time in the
blood of people with the disorder. Half of the 28 people with Crohn's tested positive for
Map.
WebMd, Sept 16, 2004
Bug May Cause Crohn's Disease
A treatable infection may be the cause of Crohn's disease, new evidence shows.
Gastroenterol Clin North Am, Sept, 2001
Infectious colitis excluding E. coli O157:H7 and C. difficile.
Colitic infection caused by a variety of organisms may have an extremely varied
presentation, course, and treatment response. Current data have provided great insights
into the pathophysiology of these various organisms and their clinical presentation,
course, and treatment outcomes.
CDC, January, 1984
Update: Sporadic Hemorrhagic Colitis
In 1983, CDC reported on investigations in Michigan and Oregon of two 1982 outbreaks of a
gastrointestinal illness designated hemorrhagic colitis (1). The illness was caused by a
previously unrecognized pathogen, Escherichia coli O157:H7. Since August 1982, sporadic
cases of this illness have been reported to CDC, and stool specimens have been examined
from patients meeting the following case definition: a person with bloody diarrhea,
abdominal cramps, and low-grade or no fever, whose stool culture is negative for
recognized pathogens including Salmonella, Shigella, Campylobacter, and Yersinia and for
ova and parasites.
CDC, March, 1983
International Notes Outbreak of Hemorrhagic Colitis -- Ottawa, Canada
In November 1982, 31 (8.8%) of 353 residents at a home for the aged in
Ottawa, Ontario, Canada, became ill with gastrointestinal symptoms. Cases occurred over an
18-day period (Figure 1). Eight of the ill patients had loose stools only, while 18 of the
23 more severely ill patients had watery, bloody diarrhea. For those with loose stools
only, illness lasted 1-2 days; for those more severely ill, illness lasted 5-12 days. Four
patients were hospitalized, and one with metastatic uterine carcinoma died. |
